Tuberculosis Drug Development: History and Evolution of the Mechanism-Based Paradigm.
Research Support, Non-U.S. Gov't
Journal:Cold Spring Harbor perspectives in medicine, Volume: 5, Issue: 8
Modern tuberculosis (TB) chemotherapy is widely viewed as a crowning triumph of anti-infectives research. However, only one new TB drug has entered clinical practice in the past 40 years while drug resistance threatens to further destabilize the pandemic. Here, we review a brief history of TB drug development, focusing on the evolution of mechanism(s)-of-action studies and key conceptual barriers to rational, mechanism-based drugs.