The relevance of persisters in tuberculosis drug discovery.

Microbiology (Reading, England), Volume: 165, Issue: 5
May 18, 2019
Soma Mandal S, Samuel Njikan S, Anuradha Kumar A, Julie V Early JV, Tanya Parish T

Bacterial persisters are a subpopulation of cells that exhibit phenotypic resistance during exposure to a lethal dose of antibiotics. They are difficult to target and thought to contribute to the long treatment duration required for tuberculosis. Understanding the molecular and cellular biology of persisters is critical to finding new tuberculosis drugs that shorten treatment. This review focuses on mycobacterial persisters and describes the challenges they pose in tuberculosis therapy, their characteristics and formation, how persistence leads to resistance, and the current approaches being used to target persisters within mycobacterial drug discovery.

Courtesy of the U.S. National Library of Medicine