The Kinetics of Bedaquiline Diffusion in Tuberculous Cavities Open a Window for the Emergence of Resistance.

Journal:

The Journal of infectious diseases, Volume: 232, Issue: 3

Published:

September 15, 2025

PMID:

40464735

Authors:

Annamarie E Bustion AE, Jacqueline P Ernest JP, Firat Kaya F, Connie Silva C, Jansy Sarathy J, Landry Blanc L, Marjorie Imperial M, Martin Gengenbacher M, Min Xie M, Matthew D Zimmerman MD, Gregory T Robertson GT, Danielle Weiner D, Laura E Via LE, Clifton E Barry CE, Radojka M Savic RM, Véronique Dartois V

Access Paper

DOI: 10.1093/infdis/jiaf303

PMID: 40464735

Abstract:

Cavitary tuberculosis is difficult to cure and constitutes a site of relapse. Bedaquiline has been a wonder drug in the treatment of multidrug-resistant tuberculosis, but emergence of resistance threatens the sustainability of its success. We designed site-of-disease pharmacokinetic studies to spatially resolve the penetration of bedaquiline, and 2 next-generation diarylquinolines, TBAJ876 and TBAJ587, in cavities.

Courtesy of the U.S. National Library of Medicine