Synthetic approaches towards bedaquiline and its derivatives.

Journal:
Bioorganic & medicinal chemistry letters, Volume: 30, Issue: 12
Published:
June 15, 2020
PMID:
32291133
Authors:
Matthew B Calvert MB, Daniel P Furkert DP, Christopher B Cooper CB, Margaret A Brimble MA
Abstract:

Bedaquiline is a diarylquinoline drug that demonstrates potent and selective inhibition of mycobacterial ATP synthase, and is clinically administered for the treatment of multi-drug resistant tuberculosis. Due to its excellent activity and novel mechanism of action, bedaquiline has been the focus of a number of synthetic studies. This review will discuss these synthetic approaches, as well as the synthesis and bioactivity of the numerous derivatives and molecular probes inspired by bedaquiline.