Standardized RS Ratio Metrics To Assess Tuberculosis Antimicrobial Efficacy and Potency.

Antimicrobial agents and chemotherapy, Volume: 67, Issue: 1
January 24, 2023
Matthew J Reichlen MJ, Sarah E M Born SEM, Michael A Lyons MA, Karen Rossmassler K, Justin Reid J, Gregory T Robertson GT, Nicholas D Walter ND, Martin I Voskuil MI

The sigmoid E model was used to describe the rRNA synthesis ratio (RS ratio) response of Mycobacterium tuberculosis to antimicrobial concentration. RS-E measures the maximal ability of a drug to inhibit the RS ratio and can be used to rank-order drugs based on their RS ratio effect. RS-EC is the concentration needed to achieve 90% of the RS-E, which may guide dose selection to achieve a maximal RS ratio effect .