Spectinamides are effective partner agents for the treatment of tuberculosis in multiple mouse infection models.
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Journal:The Journal of antimicrobial chemotherapy, Volume: 72, Issue: 3
New drug regimens employing combinations of existing and experimental antimicrobial agents are needed to shorten treatment of tuberculosis (TB) in humans. The spectinamides are narrow-spectrum semisynthetic analogues of spectinomycin, modified to avoid intrinsic efflux by Mycobacterium tuberculosis . Spectinamides, including lead 1599, have been previously shown to exhibit a promising therapeutic profile in mice as single agents. Here we explore the in vivo activity of lead spectinamides when combined with other agents.