Predictive Modeling to Study the Treatment-Shortening Potential of Novel Tuberculosis Drug Regimens, Toward Bundling of Preclinical Data.

The Journal of infectious diseases, Volume: 225, Issue: 11
June 1, 2022
Saskia E Mudde SE, Rami Ayoun Alsoud R, Aart van der Meijden A, Anna M Upton AM, Manisha U Lotlikar MU, Ulrika S H Simonsson USH, Hannelore I Bax HI, Jurriaan E M de Steenwinkel JEM

Given the persistently high global burden of tuberculosis, effective and shorter treatment options are needed. We explored the relationship between relapse and treatment length as well as interregimen differences for 2 novel antituberculosis drug regimens using a mouse model of tuberculosis infection and mathematical modeling.

Courtesy of the U.S. National Library of Medicine