Prediction of Susceptibility to First-Line Tuberculosis Drugs by DNA Sequencing.

Journal:
The New England journal of medicine, Volume: 379, Issue: 15
Published:
October 11, 2018
PMID:
30280646
Authors:
, Caroline Allix-Béguec C, Irena Arandjelovic I, Lijun Bi L, Patrick Beckert P, Maryline Bonnet M, Phelim Bradley P, Andrea M Cabibbe AM, Irving Cancino-Muñoz I, Mark J Caulfield MJ, Angkana Chaiprasert A, Daniela M Cirillo DM, David A Clifton DA, Iñaki Comas I, Derrick W Crook DW, Maria R De Filippo MR, Han de Neeling H, Roland Diel R, Francis A Drobniewski FA, Kiatichai Faksri K, Maha R Farhat MR, Joy Fleming J, Philip Fowler P, Tom A Fowler TA, Qian Gao Q, Jennifer Gardy J, Deborah Gascoyne-Binzi D, Ana-Luiza Gibertoni-Cruz AL, Ana Gil-Brusola A, Tanya Golubchik T, Ximena Gonzalo X, Louis Grandjean L, Guangxue He G, Jennifer L Guthrie JL, Sarah Hoosdally S, Martin Hunt M, Zamin Iqbal Z, Nazir Ismail N, James Johnston J, Faisal M Khanzada FM, Chiea C Khor CC, Thomas A Kohl TA, Clare Kong C, Sam Lipworth S, Qingyun Liu Q, Gugu Maphalala G, Elena Martinez E, Vanessa Mathys V, Matthias Merker M, Paolo Miotto P, Nerges Mistry N, David A J Moore DAJ, Megan Murray M, Stefan Niemann S, Shaheed V Omar SV, Rick T-H Ong RT, Tim E A Peto TEA, James E Posey JE, Therdsak Prammananan T, Alexander Pym A, Camilla Rodrigues C, Mabel Rodrigues M, Timothy Rodwell T, Gian M Rossolini GM, Elisabeth Sánchez Padilla E, Marco Schito M, Xin Shen X, Jay Shendure J, Vitali Sintchenko V, Alex Sloutsky A, E Grace Smith EG, Matthew Snyder M, Karine Soetaert K, Angela M Starks AM, Philip Supply P, Prapat Suriyapol P, Sabira Tahseen S, Patrick Tang P, Yik-Ying Teo YY, Thuong N T Thuong TNT, Guy Thwaites G, Enrico Tortoli E, Dick van Soolingen D, A Sarah Walker AS, Timothy M Walker TM, Mark Wilcox M, Daniel J Wilson DJ, David Wyllie D, Yang Yang Y, Hongtai Zhang H, Yanlin Zhao Y, Baoli Zhu B
Abstract:

The World Health Organization recommends drug-susceptibility testing of Mycobacterium tuberculosis complex for all patients with tuberculosis to guide treatment decisions and improve outcomes. Whether DNA sequencing can be used to accurately predict profiles of susceptibility to first-line antituberculosis drugs has not been clear.


Courtesy of the U.S. National Library of Medicine