Pharmacokinetics of β-Lactam Antibiotics: Clues from the Past To Help Discover Long-Acting Oral Drugs in the Future.

ACS infectious diseases, Volume: 4, Issue: 10
October 12, 2018
Paul W Smith PW, Fabio Zuccotto F, Robert H Bates RH, Maria Santos Martinez-Martinez MS, Kevin D Read KD, Caroline Peet C, Ola Epemolu O

β-Lactams represent perhaps the most important class of antibiotics yet discovered. However, despite many years of active research, none of the currently approved drugs in this class combine oral activity with long duration of action. Recent developments suggest that new β-lactam antibiotics with such a profile would have utility in the treatment of tuberculosis. Consequently, the historical β-lactam pharmacokinetic data have been compiled and analyzed to identify possible directions and drug discovery strategies aimed toward new β-lactam antibiotics with this profile.

Courtesy of the U.S. National Library of Medicine