Pharmacodynamic Correlates of Linezolid Activity and Toxicity in Murine Models of Tuberculosis.

Journal:

The Journal of infectious diseases, Volume: 223, Issue: 11

Published:

June 4, 2021

PMID:

31993638

Authors:

Kristina M Bigelow KM, Amelia N Deitchman AN, Si-Yang Li SY, Kala Barnes-Boyle K, Sandeep Tyagi S, Heena Soni H, Kelly E Dooley KE, Rada M Savic RM, Eric L Nuermberger EL

Access Paper

DOI: 10.1093/infdis/jiaa016

PMID: 31993638

Abstract:

Linezolid (LZD) is bactericidal against Mycobacterium tuberculosis, but it has treatment-limiting toxicities. A better understanding of exposure-response relationships governing LZD efficacy and toxicity will inform dosing strategies. Because in vitro monotherapy studies yielded conflicting results, we explored LZD pharmacokinetic/pharmacodynamic (PK/PD) relationships in vivo against actively and nonactively multiplying bacteria, including in combination with pretomanid.

Courtesy of the U.S. National Library of Medicine