Nonhydrolyzable d‑phenylalanine-benzoxazole derivatives retain antitubercular activity.

Journal:
Bioorganic & medicinal chemistry letters, Volume: 80
Published:
January 15, 2023
PMID:
36572353
Authors:
Michael J Pepi MJ, Shibin Chacko S, Nicole Kopetz N, Helena I M Boshoff HIM, Gregory D Cuny GD, Lizbeth Hedstrom L
Abstract:

The emergence of drug resistant Mycobacterium tuberculosis, the causative agent of tuberculosis, demands the development of new drugs and new drug targets. We have recently reported that the d-phenylalanine benzoxazole Q112 has potent antibacterial activity against this pathogen with a distinct mechanism of action from other antimycobacterial agents. Q112 and previously reported derivatives were unstable in plasma and no free compound could be observed. Here we expand the structure-activity relationship for antimycobacterial activity and find nonhydrolyzable derivatives with decreased plasma binding. We also show that there is no correlation between antibacterial activity and inhibition of PanG, a putative target for these compounds.