Linezolid pharmacokinetics in MDR-TB: a systematic review, meta-analysis and Monte Carlo simulation.

Journal:
The Journal of antimicrobial chemotherapy, Volume: 73, Issue: 7
Published:
July 1, 2018
PMID:
29584861
Authors:
James Millard J, Henry Pertinez H, Laura Bonnett L, Eva Maria Hodel EM, VĂ©ronique Dartois V, John L Johnson JL, Maxine Caws M, Simon Tiberi S, Mathieu Bolhuis M, Jan-Willem C Alffenaar JC, Geraint Davies G, Derek J Sloan DJ
Abstract:

The oxazolidinone linezolid is an effective component of drug-resistant TB treatment, but its use is limited by toxicity and the optimum dose is uncertain. Current strategies are not informed by clinical pharmacokinetic (PK)/pharmacodynamic (PD) data; we aimed to address this gap.