In silico evaluation and exploration of antibiotic tuberculosis treatment regimens.

Journal:
BMC systems biology, Volume: 9
Published:
November 14, 2015
PMID:
26578235
Authors:
Elsje Pienaar E, VĂ©ronique Dartois V, Jennifer J Linderman JJ, Denise E Kirschner DE
Abstract:

Improvement in tuberculosis treatment regimens requires selection of antibiotics and dosing schedules from a large design space of possibilities. Incomplete knowledge of antibiotic and host immune dynamics in tuberculosis granulomas impacts clinical trial design and success, and variations among clinical trials hamper side-by-side comparison of regimens. Our objective is to systematically evaluate the efficacy of isoniazid and rifampin regimens, and identify modifications to these antibiotics that improve treatment outcomes.