Hit and lead criteria in drug discovery for infectious diseases of the developing world.

Nature reviews. Drug discovery, Volume: 14, Issue: 11
November 5, 2015
Kei Katsuno K, Jeremy N Burrows JN, Ken Duncan K, Rob Hooft van Huijsduijnen R, Takushi Kaneko T, Kiyoshi Kita K, Charles E Mowbray CE, Dennis Schmatz D, Peter Warner P, B T Slingsby BT

Reducing the burden of infectious diseases that affect people in the developing world requires sustained collaborative drug discovery efforts. The quality of the chemical starting points for such projects is a key factor in improving the likelihood of clinical success, and so it is important to set clear go/no-go criteria for the progression of hit and lead compounds. With this in mind, the Japanese Global Health Innovative Technology (GHIT) Fund convened with experts from the Medicines for Malaria Venture, the Drugs for Neglected Diseases initiative and the TB Alliance, together with representatives from the Bill &Melinda Gates Foundation, to set disease-specific criteria for hits and leads for malaria, tuberculosis, visceral leishmaniasis and Chagas disease. Here, we present the agreed criteria and discuss the underlying rationale.

Courtesy of the U.S. National Library of Medicine