Establishing translational performance standards for TB therapy using rifampicin-based regimens in a male and female high-burden murine model.

Abstract:

Establishing efficacy benchmarks in preclinical tuberculosis (TB) models is essential for optimizing and prioritizing therapeutic regimens. However, standardized classification methods for comparing high-performing regimens are currently lacking. This study defines a quantitative framework utilizing rifampicin-based regimens in a high-burden aerosol BALB/c mouse model, incorporating both male and female mice to assess potential sex-specific treatment responses.