Deoxysugars as antituberculars and alpha-mannosidase inhibitors.

Journal:

Antimicrobial agents and chemotherapy, Volume: 58, Issue: 6

Published:

July 1, 2014

PMID:

24687500

Authors:

Vivek Kashyap V, Smriti Sharma S, Vinayak Singh V, Sandeep K Sharma SK, Mohammad Saquib M, Ranjana Srivastava R, Arun K Shaw AK

Access Paper

DOI: 10.1128/AAC.02715-13

PMID: 24687500

Abstract:

A promising modified sugar molecule was identified which was active against multidrug-resistant (MDR) strains of Mycobacterium tuberculosis, suggesting involvement of a new target. The compound was demonstrated to be bactericidal, inhibited the growth of M. tuberculosis in mice, and targeted alpha-mannosidase as a competitive inhibitor with a Ki value of 353.9 μM.

Courtesy of the U.S. National Library of Medicine