Cell division inhibitors with efficacy equivalent to isoniazid in the acute murine Mycobacterium tuberculosis infection model.

The Journal of antimicrobial chemotherapy, Volume: 70, Issue: 11
November 5, 2015
Susan E Knudson SE, Divya Awasthi D, Kunal Kumar K, Alexandra Carreau A, Laurent Goullieux L, Sophie Lagrange S, Hélène Vermet H, Iwao Ojima I, Richard A Slayden RA

The increasing number of clinical strains resistant to one or more of the front-line TB drugs complicates the management of this disease. To develop next-generation benzimidazole-based FtsZ inhibitors with improved efficacy, we employed iterative optimization strategies based on whole bacteria potency, bactericidal activity, plasma and metabolic stability and in vivo efficacy studies.

Courtesy of the U.S. National Library of Medicine