Cell division inhibitors with efficacy equivalent to isoniazid in the acute murine Mycobacterium tuberculosis infection model.

Journal:

The Journal of antimicrobial chemotherapy, Volume: 70, Issue: 11

Published:

November 5, 2015

PMID:

26245639

Authors:

Susan E Knudson SE, Divya Awasthi D, Kunal Kumar K, Alexandra Carreau A, Laurent Goullieux L, Sophie Lagrange S, Hélène Vermet H, Iwao Ojima I, Richard A Slayden RA

Access Paper

DOI: 10.1093/jac/dkv226

PMID: 26245639

Abstract:

The increasing number of clinical strains resistant to one or more of the front-line TB drugs complicates the management of this disease. To develop next-generation benzimidazole-based FtsZ inhibitors with improved efficacy, we employed iterative optimization strategies based on whole bacteria potency, bactericidal activity, plasma and metabolic stability and in vivo efficacy studies.