Advances in the design of combination therapies for the treatment of tuberculosis.

Expert opinion on drug discovery, Volume: 18, Issue: 1
January 28, 2023
Jonah Larkins-Ford J, Bree B Aldridge BB

Tuberculosis requires lengthy multi-drug therapy. occupies different tissue compartments during infection, making drug access and susceptibility patterns variable. Antibiotic combinations are needed to ensure each compartment of infection is reached with effective drug treatment. Despite drug combinations’ role in treating tuberculosis, the design of such combinations has been tackled relatively late in the drug development process, limiting the number of drug combinations tested. In recent years, there has been significant progress using , , and computational methodologies to interrogate combination drug effects.

Courtesy of the U.S. National Library of Medicine