Adjunctive Phosphodiesterase-4 Inhibitor Therapy Improves Antibiotic Response to Pulmonary Tuberculosis in a Rabbit Model.

Journal:
EBioMedicine, Volume: 4
Published:
February 14, 2016
PMID:
26981575
Authors:
Selvakumar Subbian S, Liana Tsenova L, Jennifer Holloway J, Blas Peixoto B, Paul O'Brien P, VĂ©ronique Dartois V, Vikram Khetani V, Jerome B Zeldis JB, Gilla Kaplan G
Abstract:

Adjunctive host-directed therapy is emerging as a new potential approach to improve the outcome of conventional antimicrobial treatment for tuberculosis (TB). We tested the ability of a phosphodiesterase-4 inhibitor (PDE4i) CC-11050, co-administered with the first-line anti-TB drug isoniazid (INH), to accelerate bacillary killing and reduce chronic inflammation in the lungs of rabbits with experimental Mycobacterium tuberculosis (Mtb) infection.