A Novel 6-Benzyl Ether Benzoxaborole Is Active against Mycobacterium tuberculosis .

Antimicrobial agents and chemotherapy, Volume: 61, Issue: 9
September 24, 2017
Nipul Patel N, Theresa O'Malley T, Yong-Kang Zhang YK, Yi Xia Y, Bjorn Sunde B, Lindsay Flint L, Aaron Korkegian A, Thomas R Ioerger TR, Jim Sacchettini J, M R K Alley MRK, Tanya Parish T

We identified a novel 6-benzyl ether benzoxaborole with potent activity against The compound had an MIC of 2 μM in liquid medium. The compound was also able to prevent growth on solid medium at 0.8 μM and was active against intracellular bacteria (50% inhibitory concentration [IC] = 3.6 μM) without cytotoxicity against eukaryotic cells (IC > 100 μM). We isolated resistant mutants (MIC ≥ 100 μM), which had mutations in Rv1683, Rv3068c, and Rv0047c.