A new in vivo model to test anti-tuberculosis drugs using fluorescence imaging.

The Journal of antimicrobial chemotherapy, Volume: 67, Issue: 8
August 25, 2012
Andrea Zelmer A, Paul Carroll P, Nuria Andreu N, Kristine Hagens K, Jacqueline Mahlo J, Natalja Redinger N, Brian D Robertson BD, Siouxsie Wiles S, Theresa H Ward TH, Tanya Parish T, Jorge Ripoll J, Gregory J Bancroft GJ, Ulrich E Schaible UE

The current method for testing new drugs against tuberculosis in vivo is the enumeration of bacteria in organs by cfu assay. Owing to the slow growth rate of Mycobacterium tuberculosis (Mtb), these assays can take months to complete. Our aim was to develop a more efficient, fluorescence-based imaging assay to test new antibiotics in a mouse model using Mtb reporter strains.

Courtesy of the U.S. National Library of Medicine