Members

Rockefeller University

Rock Laboratory

Laboratory of Host-Pathogen Biology

New York, New York USA

member since 2022

Representative

Jeremy M. Rock, Ph.D, Penrhyn E. Cook Assistant Professor

Team

  • Michael DeJesus
  • Vanisha Munsamy-Govender
  • Isaac Kresse
  • Stefany Quiñones Garcia

About

Mycobacterium tuberculosis (Mtb)is the leading cause of death due to infectious disease. By investigating the mechanisms that enable this bacterium to cause tuberculosis (TB) and evade current antibiotics, the Rock lab aims to lay the foundation for new therapeutic strategies to improve control of this epidemic.

Role & Expertise

Our mission is to develop and apply new genetic approaches to facilitate TB drug discovery.

References

  1. Li S, Poulton NC, Chang JS, Azadian ZA, DeJesus MA, Ruecker N, Zimmerman MD, Eckartt KA, Bosch B, Engelhart CA, Sullivan DF, Gengenbacher M, Dartois VA, Schnappinger D, Rock JM. CRISPRi chemical genetics and comparative genomics identify genes mediating drug potency in Mycobacterium tuberculosis, Nat Microbiol. 2022 Jun;7(6):766-779. https://doi: 10.1038/s41564-022-01130-y
  2. Bosch B, DeJesus MA, Poulton NC, Zhang W, Engelhart CA, Zaveri A, Lavalette S, Ruecker N, Trujillo C, Wallach JB, Li S, Ehrt S, Chait BT, Schnappinger D, Rock JM Genome-wide gene expression tuning reveals diverse vulnerabilities of M. tuberculosis Cell. 2021 Aug 19;184(17):4579-4592.e24. https://doi: 10.1016/j.cell.2021.06.033

Links

Rock lab

Pebble (Target Vulnerability)