Rockefeller University

Laboratory of Host-Pathogen Biology

New York, New York USA

member since 2022


Jeremy M. Rock, Ph.D, Penrhyn E. Cook Assistant Professor


  • Michael DeJesus
  • Vanisha Munsamy-Govender
  • Isaac Kresse
  • Stefany QuiƱones Garcia


Mycobacterium tuberculosis (Mtb)is the leading cause of death due to infectious disease. By investigating the mechanisms that enable this bacterium to cause tuberculosis (TB) and evade current antibiotics, the Rock lab aims to lay the foundation for new therapeutic strategies to improve control of this epidemic.

Role & Expertise

Our mission is to develop and apply new genetic approaches to facilitate TB drug discovery.


  1. Li S, Poulton NC, Chang JS, Azadian ZA, DeJesus MA, Ruecker N, Zimmerman MD, Eckartt KA, Bosch B, Engelhart CA, Sullivan DF, Gengenbacher M, Dartois VA, Schnappinger D, Rock JMCRISPRi chemical genetics and comparative genomics identify genes mediating drug potency in Mycobacterium tuberculosis, Nat Microbiol. 2022 Jun;7(6):766-779. https://doi: 10.1038/s41564-022-01130-y
  2. Bosch B, DeJesus MA, Poulton NC, Zhang W, Engelhart CA, Zaveri A, Lavalette S, Ruecker N, Trujillo C, Wallach JB, Li S, Ehrt S, Chait BT, Schnappinger D, Rock JM Genome-wide gene expression tuning reveals diverse vulnerabilities of M. tuberculosis Cell. 2021 Aug 19;184(17):4579-4592.e24. https://doi: 10.1016/j.cell.2021.06.033