An Innovative Partnership for TB Drug Discovery and Development

Breaking from traditional R&D practices, pharmaceutical companies and research institutions within the TBDA share compound libraries and data while working together to develop the best prospects—regardless of where the candidate originated. photo by John-Michael Maas for the TB Alliance (2021)

Achievements

Consortium members have advanced several compounds into clinical studies and have been recognized for their work.

Learn more about our member organizations and their research

Our membership comprises multinational institutions, the pharmaceutical and biotechnology industries, and government agencies

Recent Publications

The Tuberculosis Drug Accelerator at year 10: what have we learned?

Aldridge BB, Barros-Aguirre D, Barry CE 3rd, Bates RH, Berthel SJ, Boshoff HI, Chibale K, Chu XJ, Cooper CB, Dartois V, Duncan K, Fotouhi N, Gusovsky F, Hipskind PA, Kempf DJ, Lelièvre J, Lenaerts AJ, McNamara CW, Mizrahi V, Nathan C, Olsen DB, Parish T, Petrassi HM, Pym A, Rhee KY, Robertson GT, Rock JM, Rubin EJ, Russell B, Russell DG, Sacchettini JC, Schnappinger D, Schrimpf M, Upton AM, Warner P, Wyatt PG, Yuan Y.

Nat Med. 2021 Aug;27(8):1333-1337. doi: 10.1038/s41591-021-01442-2.
https://pubmed.ncbi.nlm.nih.gov/34226736/ 
Building and managing a complex drug discovery consortium: insights from the tuberculosis drug accelerator

Kelsey L. Briggs, Betsy J. Russell, Peter Warner, Ken Duncan, & Steven J. Berthel

Drug Discovery Today (2026): 104688.
10.1016/j.drudis.2026.104688








Strategies for shortening tuberculosis therapy

Véronique A. Dartois, Valerie Mizrahi, Radojka M. Savic, Jared A. Silverman, David Hermann & Clifton E. Barry III

Nat Med 31, 1765–1775 (2025). https://doi.org/10.1038/s41591-025-03742-3