Dynamics of within-host Mycobacterium tuberculosis diversity and heteroresistance during treatment.
Journal:
EBioMedicine, Volume: 55Abstract:
Studying within-host genetic diversity of Mycobacterium tuberculosis (Mtb) in patients during treatment may identify adaptations to antibiotic and immune pressure. Understanding the significance of genetic heteroresistance, and more specifically heterozygous resistance-associated variants (RAVs), is clinically important given increasing use of rapid molecular tests and whole genome sequencing (WGS).
Courtesy of the U.S. National Library of Medicine