Dynamics of within-host Mycobacterium tuberculosis diversity and heteroresistance during treatment.

Journal:
EBioMedicine, Volume: 55
Published:
May 28, 2020
PMID:
32361247
Authors:
Camus Nimmo C, Kayleen Brien K, James Millard J, Alison D Grant AD, Nesri Padayatchi N, Alexander S Pym AS, Max O'Donnell M, Richard Goldstein R, Judith Breuer J, Fran├žois Balloux F
Abstract:

Studying within-host genetic diversity of Mycobacterium tuberculosis (Mtb) in patients during treatment may identify adaptations to antibiotic and immune pressure. Understanding the significance of genetic heteroresistance, and more specifically heterozygous resistance-associated variants (RAVs), is clinically important given increasing use of rapid molecular tests and whole genome sequencing (WGS).